The game is set for Sunday, November 2, 2025 at Highmark Stadium in Orchard Park, New York, with kickoff scheduled at approximately **4:25 p.m. ET** (≈16:25 ET). The visiting Chiefs arrive looking to improve on their 5‑3 record, while the Bills, currently 5‑2, hope to defend home turf and solidify their AFC standing.
On the injury front: For Kansas City, running back Isiah Pacheco has been ruled out with a knee injury, and offensive tackle Josh Simmons is unavailable for personal reasons. Guard Trey Smith is listed as questionable with a back issue. Buffalo will be without defensive tackle DaQuan Jones (calf), linebacker Shaq Thompson (hamstring) and wide receiver Joshua Palmer (knee/ankle). Cornerback Taron Johnson (groin) is marked as questionable.
In terms of coaching and tactics: Chiefs head coach Andy Reid is expected to emphasize his team’s offensive continuity, relying on backup running backs to fill Pacheco’s role and leaning on quarterback Patrick Mahomes for explosive plays. Meanwhile Buffalo Bills coach Sean McDermott plans to exploit his squad’s home‑field advantage by jump‑starting the ground game early and applying pressure upfront to disrupt the Chiefs’ rhythm.
What the press is saying: Media outlets portray this matchup as one of the pivotal clashes of the week, spotlighting the history between the two clubs and the fact both are in serious contention. Many pundits give a slight edge to Kansas City because of their offensive firepower and Buffalo’s key defensive absences. Some previews project the Chiefs to edge the Bills by a narrow margin based on late‑game execution.
Studio analysts are breaking down critical match‑ups: They highlight Kansas City’s offensive line vs. Buffalo’s pass rush, Buffalo’s need to get its run game going against a Chiefs defence that has improved in run stoppage, and the importance of turnovers and special teams in this rivalry. The consensus commentary is that the team which wins the turnover battle and seizes early momentum will likely dictate the outcome.
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NFL 2025-26 Week 8 – Sunday , November 02, 2025, Kansas City Chiefs vs Buffalo Bills Full Game Replay
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