Atlanta Falcons vs San Francisco 49ers

The Atlanta Falcons will face the San Francisco 49ers on Sunday, October 19, 2025, with kickoff scheduled for 8:20 p.m. ET at Levi’s Stadium in Santa Clara, California. The game will be played under the lights in prime time, providing both teams a national stage in Week 7 of the NFL season. For the Falcons, it represents another test on the road against one of the NFC’s strongest squads, while the 49ers look to steady their campaign amid a series of key injuries.

Both teams enter the game with notable injury concerns. San Francisco 49ers will be without starting quarterback Brock Purdy, who is sidelined with a toe injury, meaning veteran Mac Jones will start in his place. Wide receiver Ricky Pearsall and defensive end Yetur Gross-Matos have also been ruled out, further limiting San Francisco’s options. On the Falcons’ side, offensive tackle Jake Matthews is questionable with an ankle problem, while rookies Jalon Walker and Billy Bowman Jr. have been declared out. Matthews’ availability will be closely monitored, as his absence would disrupt an otherwise consistent offensive line.

Tactically, Atlanta head coach Raheem Morris is expected to emphasize a balanced approach built around the running game and play-action passes to keep the 49ers’ defense guessing. The Falcons’ offense has relied on long, sustained drives, with an emphasis on controlling time of possession. On the other sideline, San Francisco’s head coach Kyle Shanahan will look to simplify the offense for Mac Jones, focusing on short, efficient passes and steady ground production from Christian McCaffrey. Shanahan’s challenge will be maintaining rhythm and efficiency without his regular starting quarterback and key offensive contributors.

The pre-game media coverage has painted the matchup as evenly poised. Many reporters have expressed concern about San Francisco’s offensive rhythm without Purdy, but others believe Shanahan’s play-calling and home-field advantage could balance the scales. Analysts have highlighted the Falcons’ recent improvement, particularly on defense, and noted this game as an opportunity to make a statement against a high-caliber opponent. Betting markets and sports journalists alike have characterized the matchup as unpredictable, with both sides having clear strengths and vulnerabilities.

Studio analysts have focused heavily on how Mac Jones adapts to Shanahan’s offense and whether Atlanta’s defensive front can capitalize on San Francisco’s weakened lineup. Some discussions have centered on the Falcons’ chance to prove they belong in the NFC playoff conversation, while others stress the 49ers’ resilience and system depth even amid injuries. The broader narrative is that this game could define the midseason trajectory for both teams — a test of depth, coaching adaptability, and composure under pressure on a national stage.

NFL 2025-26 Week 7 – Sunday, October 19, 2025, Atlanta Falcons vs San Francisco 49ers Full Game Replay

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