Tennessee Titans vs Indianapolis Colts

Lucas Oil Stadium in Indianapolis will host a crucial AFC South matchup as the Tennessee Titans take on the Indianapolis Colts on Sunday, October 26, 2025. Kickoff is scheduled for 4:25 PM ET, with national coverage on CBS. The Colts enter the game with a commanding 6–1 record, aiming to maintain their lead atop the division, while the Titans are struggling at 1–6 and looking for a breakthrough performance on the road.

Injuries are a significant factor shaping both teams’ lineups. The Titans will be without defensive tackle Jeffery Simmons due to a hamstring injury, and wide receivers Calvin Ridley and Bryce Oliver are sidelined with hamstring and knee issues. The Colts are missing cornerback Kenny Moore II, who is recovering from an Achilles injury, and running back Tyler Goodson, who is dealing with a groin problem. These absences force both teams to adjust personnel and rely on backups in key positions.

Coaching strategies are central to the game plan for each side. Colts head coach Shane Steichen is emphasizing a balanced offensive approach, relying on quarterback Daniel Jones’ efficiency and the league-leading rushing of Jonathan Taylor to control the tempo. Interim Titans head coach Mike Vrabel is focused on establishing the ground game with Derrick Henry to maintain possession and keep the Colts’ high-powered offense off the field.

Pre-game analysis highlights the mismatch in offensive efficiency and defensive stability. Commentators point to the Colts’ offensive line as a key strength, enabling Taylor to find running lanes and Jones to operate with protection. The Titans’ offense has struggled for consistency, and analysts note that breaking through Indianapolis’ defense will require precision passing and limiting turnovers.

Studio analysts are concentrating on how injuries and depth will influence the game. For the Titans, the success of Derrick Henry and the supporting running backs will be vital to keep the team competitive. For the Colts, attention is on the offensive line and skill position players to maintain scoring opportunities. Experts suggest that whichever team adapts better to personnel challenges and executes its game plan effectively is likely to emerge victorious in what could be a high-tempo, physically demanding matchup.

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NFL 2025-26 Week 8 – Sunday, October 26, 2025, Tennessee Titans vs Indianapolis Colts Full Game Replay

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