New England Patriots vs Buffalo Bills

The Week 5 NFL matchup between the New England Patriots and the Buffalo Bills is scheduled for Sunday, October 5, 2025, at Highmark Stadium in Orchard Park, New York. Kickoff is set for 8:20 PM ET, with the game being broadcast nationally on NBC as part of Sunday Night Football. The Bills enter the game as the NFL’s last unbeaten team, boasting a 4-0 record, while the Patriots are aiming to improve their 2-2 standing.

Heading into the game, both teams are managing key injuries. For the Patriots, linebacker Jahlani Tavai returns after missing the first four games due to a calf injury, providing a significant boost to the defense. Defensive tackle Milton Williams and cornerback Carlton Davis III, both previously listed as questionable, are expected to play. However, outside linebacker K’Lavon Chaisson is inactive due to a knee injury.

The Bills are without standout defensive tackle Ed Oliver, who is sidelined for the fourth consecutive game due to an ankle injury. Linebacker Matt Milano, who missed the previous two games with a pectoral issue, returns to bolster the defense.

Patriots head coach Mike Vrabel emphasizes a balanced offensive approach, aiming to control the clock and manage the game tempo. Quarterback Drake Maye, who has completed 74% of his passes this season, will look to exploit the Bills’ defense through efficient passing and strategic play-calling. Defensively, the Patriots aim to apply pressure on Bills quarterback Josh Allen, forcing him into quick decisions and potential turnovers.

Bills head coach Sean McDermott focuses on maintaining the team’s undefeated streak by leveraging Allen’s dual-threat capabilities. The offense is expected to utilize a fast-paced, high-scoring strategy, aiming to capitalize on the Patriots’ defensive adjustments. Defensively, Buffalo Bills will look to disrupt Maye’s rhythm and contain the Patriots’ rushing attack.

Leading up to the game, the press largely favors the Bills, citing their undefeated record and home-field advantage. A recent SB Nation Reacts survey indicates that only 31% of Patriots fans believe the team will win, while 38% expect a close loss. Despite this, 92% of fans express optimism about the team’s direction following a dominant 42–13 victory over the Panthers.

Analysts predict a competitive game, with the Bills favored by 7.5 points. Betting odds set the over/under at 50.5 points. Player prop bets highlight potential standout performances from both teams, including expectations for Maye and Bills running back James Cook. Analysts suggest that a clean game with no turnovers, strong clock management, and defensive pressure could give the Patriots a chance to upset the Bills.

NFL 2025-26 Week 5 – Sunday, October 05, 2025, New England Patriots vs Buffalo Bills Full Game Replay

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